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Substrate-binding pocket of Uge3 model aligns with hGalE. The hexagonal substrate-binding pocket of Uge3 model (green) was aligned to hGalE (cyan), with the six residues required for catalytic activity annotated. For Uge3 homology modeling, the N-terminal nonalignment regions were discarded, and resulting aligned sequences were modeled using Modeler Version 9.11. Bound UDP-GalNAc and NAD+ are indicated in gray at top and bottom, respectively.
