FIGURE 7.

Telethonin phosphorylation may regulate intracellular Ca²⁺ transients. A, representative whole-cell Ca²⁺_i transients measured in confocal line scan mode in ARVM infected with AdV:HA-WT-telethonin or AdV:HA-S157//161A-telethonin for 42 h. ARVM were loaded with the Ca²⁺-sensitive dye Fluo-4 and field-stimulated at 1 Hz. The quantitative data shown are the average time to peak of the Ca²⁺_i transient (B), the variance of the time to peak (C), and the average time to 50% (D) and 90% (E) decline of the Ca²⁺_i transient. *, p < 0.05; n = 25–28 cells/group.