TABLE 4.
Amino acid transporters at the plasma membranes in islet cells
The transporters are sorted according to decreasing expression levels. Essential amino acids are indicated in bold. l-dopa, l-3,4-dihydroxyphenylalanine; CIP, cation-chloride cotransporter interaction protein; T3, triiodothyronine; T4, thyroxine.
| Rank | Gene | Name | Substrates |
|---|---|---|---|
| 1721 | Slc16a10 | MCT10 (aromatic amino acid transporter1) | Phe, Tyr, Trp, T3, T4 (84) |
| 1753 | Slc7a2 | CAT-2 (cationic amino acid transporter, y + system) | Lys, Arg, ornithine (85, 86) |
| 1938 | Slc38a10 | Putative sodium-coupled neutral amino acid transporter | Unknown |
| 2488 | Slc7a5 | LAT1 (amino acid transporter light chain, L system) | His, Met, Leu, Ile, Val, Phe, Trp, Tyr, T3, T4, l-dopa (85, 86) |
| 2690 | Slc36a1 | PAT1 (proton-coupled amino acid transporter 1) | Gly, Pro, Ala, GABA, butyrate, acetate, propionate (82) |
| 2700 | Slc7a8 | LAT2 (amino acid transporter light chain, L system) | All neutral amino acids except Pro (85, 86) |
| 3054 | Slc38a2 | SNAT2 (system A amino acid transporter 2) | Ala, Cys, Ser, Gln, Asn, His, Pro, Met (81) |
| 3124 | Slc38a3 | SNAT3 (system N amino acid transporter 1) | Gln, Asn, His (81) |
| 3840 | Slc38a5 | SNAT5 (system N amino acid transporter 2) | Gln, His, Asn, Ser, Ala (81) |
| 3956 | Slc1a5 | ASCT2 (neutral amino acid transporter) | Ala, Ser, Cys, Thr, Gln (80) |
| 4120 | Slc38a4 | SNAT4 (system A amino acid transporter 3) | Gly, Ala, Cys, Ser, Asn, Met, Thr (81) |
| 4178 | Slc12a9 | CCC6 (CIP; potassium/chloride transporters) | Polyamines, amino acids |
| 4821 | Slc7a1 | CAT-1 (cationic amino acid transporter, y + system) | Lys, Arg, ornithine (85, 86) |
| 4991 | Slc6a6 | TAUT (taurine transporter) | Taurine, β-alanine (87) |
| 5179 | Slc6a9 | GLYT1 (glycine transporter 1) | Gly |
| 6136 | Slc7a6 | y + LAT2 (amino acid transporter, y + L system) | Lys, Arg, Gln, His, Met, Leu (85, 86) |