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. 2013 Dec 4;289(3):1388–1401. doi: 10.1074/jbc.M113.500033

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FIGURE 1. — Activated THP-1 cells release TNFα which increases the K⁺ current in tsA-201 cells transfected with wild-type hTASK3. a, quantity of TNFα produced by THP-1 cells activated or not by R848 in presence of tsA-201 cells (unpaired t test; ***, p ≤ 0.001). b, histogram of current density (mean ± S.E. (error bars)) after co-culture of transiently transfected tsA-201 cells with THP-1 cells. THP-1 cells (none activated; control) are compared with R848 (15-h incubation) activated THP-1 cells incubated with or without TNFα-neutralizing antibody (one-way ANOVA; **, p ≤ 0.01). c, current-voltage plot of hTASK3 current density in tsA-201 cells co-culture with THP-1 cells.