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Gp78 regulates RLR signaling. A and B, dual luciferase assays from 293T cells transfected with IFNβ promoted luciferase constructs, RIG-I, MDA5, MAVS (A), or IRF3–5D (B), and the indicated plasmids (vector or Gp78). Luciferase activity was measured 48 h post-transfection. All data are representative of at least three independent experiments and presented as mean ± S.D. (*, p < 0.01).
