FIGURE 5.

Effects of HA and Hep on HARE-mediated NF-κB activation are additive. EV (white bars) or HARE (black bars) cells were incubated with 5 or 10 nm 107-kDa HA (18) or Hep alone or in pairwise combinations and processed as in Fig. 1. Values are means ± S.E. (n = 9). The baseline for activation (1.0-fold) is indicated by a short dashed line; the calculated additive response at 5 nm is indicated by the dotted line, and the calculated additive response at 10 nm is the long dashed line (top). Values for p compare paired combinations at 5 nm with either HA or Hep alone for EV and WT: **, p < 0.005.