Table 3.
Impact of MACC1 SNP rs1990172 and rs975263 on recurrence and overall survival, shown for additive, dominant, recessive, and overdominant genetic models of inheritance
| Model | Genotype | Recurrence-free n (%) | Recurrence n (%) | HR(95% CI) | P value | Survival n (%) | Death n (%) |
HR(95% CI) | P value |
|---|---|---|---|---|---|---|---|---|---|
| rs1990172 | |||||||||
| Additive | GG | 52(85.3) | 61(68.5) | 1.36(0.96-1.91)a | 0.082a | 54(80.6) | 59(71.1) | 1.23(0.84-1.79)a | 0.284a |
| GT | 6(9.8) | 26(29.2) | 1.32(0.93-1.86)b | 0.123b | 10(14.9) | 22(26.5) | 1.11(0.75-1.64)b | 0.595b | |
| TT | 3(4.9) | 2(2.2) | 3(4.5) | 2(2.4) | |||||
| Dominant | GG | 52(85.3) | 61(68.5) | 1.87(1.20-2.94)a | 0.006a | 54(80.6) | 59(71.1) | 1.51(0.94-2.43)a | 0.090a |
| GT&TT | 9(14.8) | 28(31.5) | 1.80(1.14-2.85)b | 0.011b | 13(19.4) | 24(28.9) | 1.26(0.78-2.03)b | 0.353b | |
| Recessive | GG> | 58(95.1) | 87(97.8) | 0.51(0.12-2.06)a | 0.341a | 64(95.5) | 81(97.6) | 0.60(0.15-2.43)a | 0.471a |
| TT | 3(4.9) | 2(2.2) | 0.48(0.12-1.97)b | 0.308b | 3(4.5) | 2(2.4) | 0.64(0.16-2.62)b | 0.532b | |
| Overdominant | GG&TT | 55(90.2) | 63(70.8) | 2.30(1.45-3.64)a | 0.0004a | 57(85.1) | 61(73.5) | 1.73(1.06-2.830)a | 0.028a |
| GT | 6(9.8) | 26(29.2) | 2.27(1.41-3.66)b | 0.001b | 10(14.9) | 22(26.5) | 1.39(0.84-2.29)b | 0.198b | |
| rs975263 | |||||||||
| Additive | TT | 49(80.3) | 58(65.2) | 1.23(0.87-1.74)a | 0.248a | 51(76.1) | 56(67.5) | 1.09(0.75-1.60)a | 0.642a |
| CT | 8(13.1) | 30(33.7) | 1.25(0.88-1.77)b | 0.215b | 12(17.9) | 26(31.3) | 1.05(0.71-1.54)b | 0.825b | |
| CC | 4(6.6) | 1(1.1) | 4(6.0) | 1(1.2) | |||||
| Dominant | TT | 49(80.3) | 58(65.2) | 1.62(1.05-2.51)a | 0.031a | 51(76.1) | 56(67.5) | 1.32(0.83-2.09)a | 0.241a |
| CT&CC | 12(19.7) | 31(34.8) | 1.69(1.09-2.63)b | 0.020b | 16(23.9) | 27(32.5) | 1.21(0.76-1.93)b | 0.413b | |
| Recessive | TT&CT | 57(93.4) | 88(98.9) | 0.25(0.03-1.76)a | 0.162a | 63(94.0) | 82(98.8) | 0.28(0.04-2.03)a | 0.209a |
| CC | 4(6.6) | 1(1.1) | 0.23(0.03-1.66)b | 0.145b | 4(6.0) | 1(1.2) | 0.29(0.04-2.12)b | 0.224b | |
| Overdominant | TT&CC | 53(86.9) | 59(66.3) | 2.00(1.28-3.11)a | 0.002a | 55(82.1) | 57(68.7) | 1.56(0.98-2.49)a | 0.061a |
| CT | 8(13.1) | 30(33.7) | 2.16(1.37-3.39)b | 0.001b | 12(17.9) | 26(31.3) | 1.42(0.88-2.27)b | 0.148b |
a Hazard ratios (HR) and 95% confidence intervals (95% CI) were obtained from univariate Cox regression analysis.
b Hazard ratios (HR) and 95% confidence intervals (95% CI) were obtained from multivariate Cox regression analysis.