Table 3.
Correlation between TGR5 methylation status and clinicopathological parameters in HCC patients
| TGR5 methylation status | ||||
|---|---|---|---|---|
| Parameters | Total number | Methylated (%) | Unmethylated (%) | P value |
| Gender | 0.827 | |||
| Male | 132 | 63(48%) | 69(52%) | |
| Female | 28 | 14(50%) | 14(50%) | |
| Age (yr) | 0.019* | |||
| ≤60 | 106 | 44(42%) | 62(58%) | |
| >60 | 54 | 33(61%) | 21(39%) | |
| HBeAg | 0.747 | |||
| negative | 125 | 61(49%) | 64(51%) | |
| positive | 35 | 16(46%) | 19(54%) | |
| Smoking | 0.893 | |||
| No | 84 | 40(48%) | 44(52%) | |
| Yes | 76 | 37(49%) | 39(51%) | |
| Alcohol | 0.908 | |||
| No | 99 | 48(48%) | 51(51%) | |
| Yes | 61 | 29(48%) | 32(52%) | |
| Primary tumor number | 0.571 | |||
| single | 94 | 47(50%) | 47(50%) | |
| multiple | 66 | 30(45%) | 36(55%) | |
| Tumor size | 0.494 | |||
| ≤3cm | 52 | 23(44%) | 29(56%) | |
| >3cm | 108 | 54(50%) | 54(50%) | |
| Histological grading | 0.458 | |||
| poor | 48 | 22(46%) | 26(54%) | |
| moderate | 83 | 38(46%) | 45(54%) | |
| well | 29 | 17(59%) | 12(41%) | |
| Venous invasion | 0.765 | |||
| negative | 83 | 39(47%) | 44(53%) | |
| positive | 77 | 38(49%) | 39(51%) | |
| TNM staging | 0.472 | |||
| I/II | 94 | 43(46%) | 51(54%) | |
| III/IV | 66 | 34(52%) | 32(48%) | |
| Okuda staging | 0.225 | |||
| I/II | 144 | 67(47%) | 77(53%) | |
| III | 16 | 10(63%) | 6(37%) | |
| CTP staging | 0.354 | |||
| A/B | 154 | 73(47%) | 81(53%) | |
| C | 6 | 4(67%) | 2(33%) | |
*, significant difference (P<0.05); TNM, Tumor Node Metastasis; CTP, Child-Turcotte-Pugh