Table 4.
Diagnostic value of AFP and TGR5 methylation combined AFP for discriminating HCC from CHB patients at different cut-off points
| Model | Cut-off points of AFP (ng/mL) |
All patients | CHB patients | HCC patients | Sensitivity (%) | Specificity (%) | Youden index |
|---|---|---|---|---|---|---|---|
| AFP alone | n=248 | n=88 | n=160 | ||||
| ≤20 | 109 | 42 | 67 | ||||
| >20 | 139 | 46 | 93 | 58.13 | 47.73 | 0.06 | |
| ≤200 | 192 | 81 | 111 | ||||
| >200 | 56 | 7 | 49 | 30.63 | 92.05 | 0.23 | |
| ≤400 | 208 | 87 | 121 | ||||
| >400 | 40 | 1 | 39 | 24.38 | 98.86 | 0.23 | |
| TGR5 combined AFP | n=248 | n=88 | n=160 | ||||
| ≤20 | 64 | 34 | 30 | ||||
| >20 | 184 | 54 | 130 | 81.25 | 38.64 | 0.20 | |
| ≤200 | 120 | 69 | 51 | ||||
| >200 | 128 | 19 | 109 | 68.13 | 78.41 | 0.47 | |
| ≤400 | 131 | 75 | 56 | ||||
| >400 | 117 | 13 | 104 | 65.00 | 85.23 | 0.50 |