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. 2014 Jan 1;28(1):20–33. doi: 10.1101/gad.229518.113

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© 2014 Tasdemir-Yilmaz and Freeman; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 6. — EcR, Draper, and Crk/Mbc/dCed-12 function in astrocytes to promote clearance of vCrz⁺ neuronal debris. (A) vCrz⁺ neurons were labeled with anti-Crz (green) in A and B. Time points used were as follows: L3 (third instar larva). Genotypes used were as follows: control (alrm-Gal4, UAS-mCD8∷GFP/+) and alrm>EcR^DN (alrm-Gal4, UAS-mCD8∷GFP/UAS-EcR^DN). Confocal images in A and B are z-projection images. Bars, 20 μm. (B) Time points are as indicated in A. Bars, 20 μm. Genotypes used were as follows: control (alrm-Gal4/+), alrm>drpr^RNAi (alrm-Gal4/drpr^RNAi), drpr^Δ5 (alrm-Gal4/+; drpr^Δ5), alrm>dCed-12^RNAi (alrm-Gal4/dCed-12^RNAi), and alrm>dCed-12^RNAi+drpr^Δ5 (alrm-Gal4/dCed-12^RNAi; drpr^Δ5). (C) Quantification of pixel intensity of vCrz⁺ debris from B. (C,D) N-values are as follows: alrm-Gal4/+, N = 32; alrm-Gal4/drpr^RNAi, N = 11; alrm-Gal4/+; drpr^Δ5, N = 11; alrm-Gal4/dCed-12^RNAi, N = 14; and alrm-Gal4/dCed-12^RNAi; drpr^Δ5, N = 12 brains quantified. Error bars represent ±SEM. (****) P < 0.0001. (D) Quantification of the percentage of remaining vCrz⁺ cell bodies from B. Error bars represent ±SEM. (****) P < 0.0001.