Fig. 5.

Genetic organisation of the centromeric region of the LILR gene cluster encompassing LILRB5, LILRB3 and LILRA6. a Genes are arranged according to their positions as determined by analysis of the representative sequence CU151838 (i) and within fosmid AC236241 (ii). Sequence AC236241 carries two copies of LILRA6 (labelled 1 and 2) and a 570-bp deletion within the tandem repeat region present in CU151838. The comparative homology between these two sequences is also presented. Regions occurring within both LILRB3 and LILRA6 that share >95 % identity are indicated, together with the locations of LILRA6-specific sequence within AC236241. The AC236241 sequence terminates within the 3′ region of LILRA6 (2). b PCR-based detection of the deleted region identified within fosmid AC236241. Amplification of the tandem repeat sequence between LILRB3 and LILRA6 (918 bp) or two LILRA6 sequences (348 bp). Samples are DEM (1), DUCAF (2), HOR (3), and SA (4). The arrow indicates the direction of DNA migration. Refer to Table 3 for information about the results of LILRA6 copy number, the deletion within the tandem repeat sequence and results for the SNP 94 T by SSP-PCR