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Renal regulation of magnesium homeostasis. Model of thick ascending limb (TAL) and distal convoluted tubule (DCT), showing predominant magnesium transport pathways9). CLCKb, voltage-dependent chloride channel; claudin-16, paracellin; NKA, Na+,K+-ATPase; NKCC2, Na+/K+/2Cl- cotransporter; ROMK, inwardly rectifying potassium channel; TSC, thiazide-sensitive Na+/Cl- cotransporter.
