Table 1. Summary of multiple readouts from quantitative image-based therapeutic assessment comparing measured outcomes by drug type and mechanism of action for 5 agents evaluated in this study.
| Classification | qVISTA readouts | |||||
|---|---|---|---|---|---|---|
| Agent | Class | Relative Toxicity (Clinical) | Cytotoxicity | Growth Inhibition | Heterogeneity | Architectural Disruption (Dfrac) |
| Carboplatin | Alkylating agent (platinum) | High | High | High | Moderate | Low |
| Etoposide | Topoisomerase II inhibitor | High | Moderate | High | Moderate | Low |
| Paclitaxel | Microtubule disassembly inhibitor | High | High | High | Low | High |
| Gemcitabine | Nucleoside analog | Low | Low | Moderate | Low | Low |
| PDT (verteporfin) | Photochemistry-based modality | High (Localized) | High | Moderate | High | High |