. Author manuscript; available in PMC: 2014 Jan 17.

Published in final edited form as: Genet Epidemiol. 2010 Nov;34(7):756–768. doi: 10.1002/gepi.20534

Table 5.

Four analytical methods¹ applied to UMLYNCH and DLYNCH. ‘Only CRC’ considers those parent-child pairs where both had colorectal cancer and, for DLYNCH, ‘MSH2’, ‘MLH1’ and ‘MSH6’ stratify by mutation type.

Subset	UMLYNCH						DLYNCH
	Difference		Test Statistics^Significance				Difference		Test Statistics^Significance
	pairs(n)	in means	t-test	HV²	RY1³	RY2³	pairs(n)	in means	t-test	HV²	RY1³	RY2³
Entire cohort	136	9.89	5.65^***	1.89	0.00	2.47^*	290	8.72	7.77^***	4.10^***	2.60^*	4.67^***
Only CRC	62	11.19	4.53^***	1.82	−0.10	2.28	130	11.01	6.68^***	4.25^***	2.01	3.85^***
MSH2							153	7.58	5.13^***	2.85^*	2.09	2.86^*
MLH1	Not Analyzed Due to Missingness						92	10.10	4 28^***	2.51^*	1.21	3.74^***
MSH6							41	9.76	4 29^***	1.74	1.05	2.08

With adjustments to the variance estimates for correlation of multiple pairs coming from the same family.

Huang and Vieland [1997]

Rabinowitz and Yang [1999]

^***

indicates a p-value less than 0.0001,

^**

less than 0.001, and

less than 0.01.