. Author manuscript; available in PMC: 2014 Jan 17.

Published in final edited form as: Genet Epidemiol. 2010 Nov;34(7):756–768. doi: 10.1002/gepi.20534

Table A.1.

Four analytical methods¹ applied to UMLYNCH and DLYNCH. ‘Only CRC’ considers those parent-child pairs where both had colorectal cancer and, for DLYNCH, ‘MSH2’, ‘MLH1’ and ‘MSH6’ stratify by mutation type.

Subset	UMLYNCH						DLYNCH
	Difference		Test Statistics^Significance				Difference		Test Statistics^Significance
	pairs(n)	in means	t-test	HV²	RY1³	RY2³	pairs(n)	in means	t-test	HV²	RY1³	RY2³
Entire cohort	136	9.89	7.42^***	3.11^**	0.00	3.05^*	290	8.72	9.84^***	4.73^***	2.97^*	5.39^***
Only CRC	62	11.19	5.06^***	2.74^*	−0.18	2.85^*	130	11.01	8.54^***	4.41^***	2.65^*	4.89^***
MSH2							153	7.58	6.38^***	3.33^**	2.51^*	3.59^**
MLH1	Not Analyzed Due to Missingness						92	10.10	6.18^***	2.89^*	1.21	3.75^***
MSH6							41	9.76	4.32^***	1.90	1.13	2.00

With no adjustments to the variance estimates for correlation of multiple pairs coming from the same family. These results are obtained by direct use of the test statistics as proposed in the original papers.

Huang and Vieland [1997]

Rabinowitz and Yang [1999]

^***

indicates a p-value less than 0.0001,

^**

less than 0.001, and

less than 0.01.