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. Author manuscript; available in PMC: 2014 Dec 23.
Published in final edited form as: Biochemistry. 2013 Nov 26;52(51):9375–9384. doi: 10.1021/bi401077f

FIGURE 1.

FIGURE 1

Identification of major scaffolds of Mtb Lpd inhibitors (A) and characterization of triazinediones (B) and quinoxaline (C) compounds as Lpd inhibitors. Pure recombinant mLpd (closed circles), hLpd (open circles) or mycobacterial PDH complex (open squares) were tested against the hit compounds (structures shown in the inset) from freshly prepared stocks or after incubation of compound stocks in DMSO at RT (closed squares) for 10 days. Compounds toxicity (closed triangles) was assessed against monkey kidney Vero cell line by MTS assay.