FIG. 10.

Synergistic effect of KGF and Dex on induction of PRDX6 promoter activity. The effect of the combination of KGF and Dex on reporter gene activity in response to the human PRDX6 promoter is shown. The effect of each individual treatment is shown for comparison. The basal level of reporter gene activity is set to 1. Cells were transiently transfected with reporter vectors; after 24 h, cells were incubated with 20 ng/ml of KGF, 1 μM Dex, or both. SEAP activity was determined 24 h after treatment. Cells were then harvested, and reporter gene assays performed. Mean±SE (n=3) are shown. *p<0.05 compared with untreated control, †p<0.01 compared with untreated control.