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. 2014 Jan 20;20(3):460–473. doi: 10.1089/ars.2013.5371

FIG. 4.

FIG. 4.

The activity of the class III PtdIns3K complex is regulated by subunit composition. The ATG14 complex (ATG14-BECN1-PIK3C3-PIK3R4) is required for macroautophagy. It can be positively regulated by AMBRA1 and negatively regulated by BCL2 binding to BECN1 and preventing association with the complex. The UVRAG (UVRAG-BECN1-PIK3C3-PIK3R4) complex is involved in the endocytic pathway and also participates in macroautophagy. SH3GLB1/Bif-1 positively regulates this complex by binding UVRAG. The KIAA0226/Rubicon complex (KIAA0226-UVRAG-BECN1-PIK3C3-PIK3R4) negatively regulates macroautophagy. This figure was modified from Figure 1 in Yang and Klionsky (154). To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars