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. Author manuscript; available in PMC: 2014 Jan 17.
Published in final edited form as: Nature. 2011 Jul 17;475(7357):528–531. doi: 10.1038/nature10218

Figure 4. Structural comparison between FlaK and presenilin-1.

Figure 4

a, Topology diagrams of FlaK and presenilin. The three key TM segments are highlighted in red. The grey boxes represent membrane. Arrows indicate the direction of the helices (N to C termini). b, FlaK viewed from the cytosolic side of the membrane. Asp 18, the GXGD motif and the conserved Pro 204 are shown in yellow. The two conserved leucines are shown as stick models. c, Packing of the three key TM helices in presenilin. This model is similar to the one proposed in ref. 27, but is the mirror image of another model22. Leu 250 from TM6 is hypothesized to mediate packing with TM7 (through Leu 392) and TM9.