FIG. 3.

Post-translational modifications regulate inflammasomes. (a) NLRP1 is cleaved in the N-terminus or FIIND domain in the presence of LeTx to activate the NLRP1 inflammasome (17, 30). (b) Deubiquitination of NLRP3 by BRCC3 is required for NLRP3 inflammasome activation (44, 57, 71). (c) Phosphorylation of serine 533 by PKCδ is required for NLRC4 inflammasome activation (72). (d) Ubiquitination of ASC leads to p62-directed autophagosomal degradation of the AIM2/ASC inflammasome (84). BRCC3, BRCA1-BRCA2-containing complex 3; LeTx, anthrax lethal toxin; ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars