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Augophagosomal degradation negatively regulates inflammasomes. TLR activation results in the sequestration of pro-IL-1β to autophagosomal compartments, leading to reduced levels of pro-IL-1β (38). In parallel, ASC is targeted for K63-liked ubiquitination upon AIM2 stimulation, which results in localization of ASC to autophagosomes (85). To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars
