Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Structures of clozapine and isoclozapine, which have similar inhibition constants Ki at serotonin 5HT2A receptors (Table 1). Clozapine has Ki = 75 nM at the D2 receptor and does not elicit parkinsonism. Isoclozapine has Ki = 15 nM but causes catalepsy, indicating that the absolute value of Ki of D2 (rather than that for the 5HT2A receptor) determines whether or not parkinsonism occurs.
