Figure 5. Noggin reduces formation of autophagic vacuoles in CR-induced AP demonstrated by transmission electron microscopy (TEM).
Fresh pancreatic tissue samples were obtained from one mouse from each group described in Figure 3 and prepared for TEM studies. The pancreas from the mouse treated with PBS alone was included as a baseline control. Representative images were acquired from A. PBS control, B. CR, C. N+CR. Arrow head: zymogene granule. Asterisk: nucleus. Arrow: autophagic vacuole.