Demographics and clinical characteristics
| Clinical Cohort | All RICE | RICE I | RICE II | |||||
|---|---|---|---|---|---|---|---|---|
| Mean age (range) | 45.1 | (18–85) | 46.0 | (18–92)* | 45.7 | (18–92) | 46.4 | (18–92)* |
| % Race: | ||||||||
| White | 83.0 | 74.7† | 70.9 | 80.1‡ | ||||
| Black | 6.5 | 9.9* | 11.4 | 7.7† | ||||
| Hispanic | 3.6 | 10.8‡ | 13.1 | 7.4‡ | ||||
| Other | 6.9 | 4.7* | 4.6 | 4.8* | ||||
| Social: | ||||||||
| % Married | 74.3 | 58.1‡ | 57.8 | 58.4* | ||||
| Mean No. children | 1.4 | 2.2‡ | 2.2 | 2.3* | ||||
| % Employment: | ||||||||
| Full-time | 39.3 | 35.6* | 36.5 | 34.3* | ||||
| Part-time | 13.4 | 17.4* | 16.8 | 18.3* | ||||
| Not employed | 47.3 | 47* | 46.7 | 47.4* | ||||
| Mean uninsured subjects | 2.2 | 13.4‡ | 13.9 | 12.7* | ||||
| Symptoms: | ||||||||
| Mean yrs bladder symptoms (SE) | 13.6 | (0.77) | 14.6 | (0.26)* | 14.6 | (0.35) | 14.6 | (0.38)* |
| Mean max pain (scale 1–10, previous 3 mos) | 8.0 | 6.6‡ | 6.5 | 6.8‡ | ||||
| Mean baseline pain (scale 1–10, previous 3 mos) | 5.9 | 5.4‡ | 5.4 | 5.4* | ||||
| Mean ICSI (range) | 11.3 | (0–20) | 10.7 | (1–20)§ | 10.1 | (1–20) | 11.5 | (1–20)‡ |
| % Diagnostic tests + findings: | ||||||||
| Hydrodistention | 75.4 | 12.9‡ | 11.8 | 14.4* | ||||
| Glomerulations | 30.1 | 2.4‡ | 1.4 | 3.9* | ||||
| Ulcers | 17.6 | 0.4‡ | 0.2 | 0.6* | ||||
| % Medication use (previous 3 mos): | ||||||||
| Amitriptlyline | 34.4 | 4.0‡ | 4.0 | 4.0* | ||||
| Pentosan polysulfate | 40.4 | 2.0‡ | 1.1 | 3.3† | ||||
| Hydroxyzine | 21.3 | 2.2‡ | 2.4 | 1.9* | ||||
| Dimethyl sulfoxide | 7.2 | 0.5‡ | 0.4 | 0.7* | ||||
| For incontinence/urgency | 15.9 | 12.9* | 11.9 | 14.3* | ||||
| For anxiety | 42.2 | 19.9‡ | 18.9 | 21.4* | ||||
| % Concomitant diagnoses: | ||||||||
| Fibromyalgia | 20.0 | 11.2‡ | 9.9 | 13.0§ | ||||
| Chronic fatigue syndrome | 14.1 | 6.3‡ | 5.9 | 7* | ||||
| Irritable bowel syndrome | 46.4 | 22.0‡ | 19.4 | 25.8‡ | ||||
| Chronic sinusitis | 20.7 | 17.6* | 17.1 | 18.3* | ||||
| Migraine | 19.3 | 17.5* | 17.1 | 18.1* | ||||
| Vulvodynia | 16.8 | 0.4‡ | 0.3 | 0.5* | ||||
| Overactive bladder | 29.5 | 24.8* | 23.3 | 26.9§ | ||||
| Panic attacks | 14.1 | 23.4‡ | 22.0 | 25.4* | ||||
| Endometriosis | 33.3 | 17.1‡ | 18.1 | 15.6* | ||||
| Impact/quality of life: | ||||||||
| % Work loss | 35.38 | 12.98‡ | 11.60 | 14.96§ | ||||
| Mean ICPI (range) | 9.9 | (0–16) | 13.2 | (4–20)‡ | 12.5 | (4–20) | 14.2 | (4–20)‡ |
| Mean SF-36 Mental Composite Score (range) | 44.9 | (15.5–68.8) | 45.1 | (12.3–69.9)* | 45.3 | (12.3–67.9) | 44.8 | (12.3–69.9)* |
| Mean SF-36 Physical Composite Score (range) | 38.7 | (2.5–64.9) | 40.9 | (0.5–67)§ | 42.1 | (0.5–67) | 39.3 | (0.3–66.6)‡ |
*
Not significant.
†
p <0.01.
‡
p <0.001.
§
p <0.05.