Figure 7. Sharing of TCR Sequences between Areg⁺ Splenic and Muscle-Infiltrating Treg Cells.

(A) TCRCDR3 α and β sequences for individual Areg⁺ splenic Treg cells. Each pie chart represents a single mouse. n, number of analyzed sequences per mouse. Total frequency of expanded clones shown at the top right.

(B) Identical paired CDR3 α (data not shown) and β sequences found in splenic Areg⁺ and muscle Areg⁺ and Areg⁻ Treg cells from the same individual in independent experiments. #: number of times the sequence was found. %: frequency of Tregs expressing the same sequence.

(C) As in (A), for muscle Treg cells. Clones represented in Areg⁺, Areg⁻, or both subsets of muscle Tregs were labeled in red, blue, and green, respectively. See also Table S2.