Table 2.

SIV-specific single cytokine T cell responses

Tissue	Time (wks)	SIV Gag					SIV Env
		IL-2	IFN-γ	IL-17A	TNF-α	Animal No. (%)	IL-2	IFN-γ	IL-17A	TNF-α	Animal No. (%)
PBMC
CD4+T	3	0.068	0.043–0.255	0.061–0.109	0.028–0.207	7/8 (88)	NT	NT	NT	NT
	6	0.040–0.217	NS	0.056–0.072	0.011–0.016	6/8 (75)	0.030	NS	0.081	0.023	3/4 (75)
	8	0.175	NS	0.113	NS	2/8 (25)	0.038	NS	0.051	0.014	3/6 (50)
	16–18	0.050	NS	0.062–0.136	0.010–0.015	5/8 (63)	0.016–0.096	0.014–0.025	0.045–0.202	0.013–0.019	6/8 (75)
CD8+T	3	0.131–0.181	0.125–1.329	0.077–0.233	0.056–0.281	8/8 (100)	NT	NT	NT	NT
	6	0.224	0.050–0.100	0.181	0.022–0.096	5/8 (63)	NS	0.063	0.069	0.039–0.044	3/4 (75)
	8	0.219	0.065	0.129	0.022–0.049	5/8 (63)	NS	0.012–0.174	0.041	0.030	4/6 (67)
	16–18	0.048–0.062	0.038–0.063	0.104–0.124	0.080	6/8 (75)	0.139	0.018–0.049	0.089–0.240	0.025–0.120	7/8 (88)
Tonsil
CD4+T	16–18	0.167	NS	0.196	NS	3/8 (38)	0.015–0.126	NS	0.155	0.019–0.028	5/5 (100)
CD8+T	16–18	0.013–0.213	0.027–0.027	0.176–0.572	0.095–0.105	6/8 (75)	0.042–0.227	NS	0.412	0.053–0.190	5/5 (100)
Subm. LN
CD4+T	16–18	NS	NS	NS	NS	0/8 (0)	0.011–0.013	NS	NS	0.018	3/8 (38)
CD8+T	16–18	0.010–0.018	0.011–0.016	NS	NS	4/8 (50)	0.035–0.048	0.012	NS	0.010–0.030	7/8 (88)
Ileum
CD4+T	16–18	0.058–0.174	0.021–0.144	0.165–0.900	0.144–0.396	6/7 (86)	0.0221–0.075	0.024–0.242	0.315–0.395	0.241–0.499	7/7 (100)
CD8+T	16–18	0.023–0.294	0.011–0.077	0.426	0.026–0.878	7/7 (100)	0.064	NS	0.090–1.065	0.032–1.008	7/7 (100)
Colon
CD4+T	16–18	0.333	0.290	0.118	0.029	3/8 (38)	0.228–0.711	0.033–0.920	0.010–0.130	0.011–0.019	6/8 (75)
CD8+T	16–18	0.143–0.625	0.043–1.130	NS	0.069–0.237	4/8 (50)	0.022–0.505	0.015–0.820	0.050–0.161	0.156–0.193	6/8 (75)
Mes. LN
CD4+T	16–18	NS	0.010	0.025–0.464	0.016–0.033	6/8 (75)	0.010	0.014	0.101	0.033	5/8 (63)
CD8+T	16–18	0.022–0.029	NS	0.024–0.568	0.062–0.121	7/8 (88)	0.012–0.048	0.027	0.075	0.049–0.073	6/8 (75)
Ax. LN
CD4+T	16–18	NS	NS	NS	NS	0/8 (0)	NS	NS	NS	0.016	1/8 (13)
CD8+T	16–18	NS	0.052	NS	0.053–0.19	5/5 (100)	0.047–0.062	NS	NS	0.073–0.083	3/8 (38)