Skip to main content
. Author manuscript; available in PMC: 2014 Nov 27.
Published in final edited form as: J Med Chem. 2013 Nov 11;56(22):9251–9264. doi: 10.1021/jm401334s

Table 3.

Lead BrD Inhibitors against a Panel of BrDs

BrD Protein 27 (MS436)
Ki µM		 4 (MS435)
Ki µM		 28 (MS267)
Ki µM		 29 (MS363)
Ki µM
BRD4-BrD1 <0.085 0.91 0.15 0.17
BRD4-BrD2 0.34 4.30 0.45 0.64
BRD3-BrD1 0.10 1.64 0.29 0.24
BRD3-BrD2 0.14 2.48 0.22 0.32
CBP 2.18 7.15 5.12 5.59
PCAF 5.52 -- <3.34 <3.34
BRD7 2.72 3.54 <1.43 <1.43
BPTF 6.06 -- <1.7 1.62
BAZ2b 3.29 -- 2.26 3.30
SMARCA4 7.97 <6.56 <6.56 <6.56