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. Author manuscript; available in PMC: 2014 Dec 12.
Published in final edited form as: J Med Chem. 2013 Dec 2;56(23):9709–9724. doi: 10.1021/jm4014136

Scheme 5.

Scheme 5

Synthesis of N-substituted analogues of 1a

aReagents and conditions: (a) (i) ACE-Cl, K2CO3, DCE, reflux, 4 h; (ii) MeOH, reflux, 2 h; (b) corresponding aldehyde, Na(OAc)3BH, CH3COOH, dichloroethane, RT, 12 h; (c) K2CO3, MeOH, reflux, 2 h.