Table 2.

Binding Data for 5- and 4’-substituted analogues of 1^a

Compd	Structure	R	R’	SERT Ki±SEM (nM)	NET Ki±SEM (nM)	Ki (NET)/Ki (SERT)
24	B	CN	Br	50.9±3.89	17% b	>10,000
25	A	CN	Br	11.4±0.74	45% b
26	A	CN		38.0±4.21	44% b	>10,000
27	A	CN		51.5±6.63	2800±353	54
28	A	CN		125±15.2	7020±581	56
37	C	_	_	681±88.2	4970±738	7.3

^aThese novel analogues were assessed by radioligand binding displacement of [³H]1 (for SERT) and [³H]nisoxetine (for NET) in rat brain stem and frontal cortex, respectively.³⁵

^b% Displacement at 10 µM.