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The distance changes between the atoms C1 of heptanoic acid, OH of Ser82 (black), OH of Tyr41 (light), and OH of Ser83 (dotted) of S86, over the duration of the simulation. The figure shows competing electrostatic interactions. These interactions are sustained for most of the simulation. The lack of a single strong electrostatic tether is probably what affects the binding of this ligand to S86. Heptanoic acid is a nonactivator of S86.
