Table 3. Genes Downregulated in the Lungs of HDM-treated DDAH1-transgenic Mice versus HDM-treated Wild Type Mice.
| Symbol | Name | Fold Change |
| Metabolism/Transport | ||
| Fbp1 | fructose bisphosphatase 1 | 0.1302 |
| Dhrs9 | dehydrogenase/reductase (SDR family) member 9 | 0.1595 |
| Arg1 * | arginase, liver | 0.1808 |
| Slc26a4 | solute carrier family 26, member 4 | 0.2789 |
| Cox15 | COX15 homolog, cytochrome c oxidase assembly protein (yeast) | 0.2889 |
| Chi3l4 * | chitinase 3-like 4 | 0.3373 |
| Atp1a3 | ATPase, Na+/K+ transporting, alpha 3 polypeptide | 0.3547 |
| Slc5a1 | solute carrier family 5 (sodium/glucose cotransporter), member 1 | 0.3701 |
| Clca3 | chloride channel calcium activated 3 | 0.3773 |
| Kcnj15 | potassium inwardly-rectifying channel, subfamily J, member 15 | 0.4207 |
| Chi3l3 * | chitinase 3-like 3 | 0.4246 |
| Slco4c1 | solute carrier organic anion transporter family, member 4C1 | 0.4487 |
| Man2b2 | mannosidase 2, alpha B2 | 0.4520 |
| Immune/Defense Response | ||
| Ear11 | eosinophil-associated, ribonuclease A family, member 11 | 0.2201 |
| Chia * | chitinase, acidic | 0.3222 |
| Sod3 | superoxide dismutase 3, extracellular | 0.3353 |
| Csf2ra | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 0.3959 |
| Ifitm2 | interferon induced transmembrane protein 2 | 0.4031 |
| Igf1 | insulin-like growth factor 1 | 0.4424 |
| Osmr | oncostatin M receptor | 0.4612 |
| Cytokine/Chemokine | ||
| Ccl22 | chemokine (C-C motif) ligand 22 | 0.2776 |
| Tnfsf12 | tumor necrosis factor (ligand) superfamily, member 12 | 0.3065 |
| Ccl9 | chemokine (C-C motif) ligand 9 | 0.4578 |
| Il33 * | interleukin 33 | 0.4640 |
| Extracellular Matrix | ||
| Col6a2 | collagen, type VI, alpha 2 | 0.3976 |
| Muc5ac | mucin 5, subtypes A and C, tracheobronchial/gastric | 0.4245 |
| Muc4 | mucin 4 | 0.4415 |
| Col1a1 | collagen, type I, alpha 1 | 0.4641 |
| Transcriptional Factor | ||
| Srebf2 | sterol regulatory element binding factor 2 | 0.3294 |
| Foxp4 | forkhead box P4 | 0.3743 |
| Nfic | nuclear factor I/C | 0.4391 |
| MicroRNA | ||
| Mir5109 | microRNA 5109 | 0.2007 |
| Mir5107 | microRNA 5107 | 0.4523 |
| Other | ||
| Syn2 | synapsin II | 0.0688 |
| 4833422F24Rik | RIKEN cDNA 4833422F24 gene | 0.0775 |
| LOC100048885 | major urinary protein LOC100048885 | 0.1392 |
| Corin | corin | 0.1992 |
| Zfp366 | zinc finger protein 366 | 0.2274 |
| Zfp385b | zinc finger protein 385B | 0.2356 |
| Epha7 | Eph receptor A7 | 0.2597 |
| Bahcc1 | BAH domain and coiled-coil containing 1 | 0.2673 |
| Actg2 | actin, gamma 2, smooth muscle, enteric | 0.2694 |
| Phlda1 | pleckstrin homology-like domain, family A, member 1 | 0.2729 |
| Actc1 | actin, alpha, cardiac muscle 1 | 0.2852 |
| BC048546 | cDNA sequence BC048546 | 0.2998 |
| Trim65 | tripartite motif-containing 65 | 0.3015 |
| Bin2 | bridging integrator 2 | 0.3016 |
| Fcgbp | Fc fragment of IgG binding protein | 0.3248 |
| Prrc2a | proline-rich coiled-coil 2A | 0.3288 |
| Dusp8 | dual specificity phosphatase 8 | 0.3328 |
| Rhob | ras homolog gene family, member B | 0.3346 |
| Atn1 | atrophin 1 | 0.3370 |
| Rpph1 | ribonuclease P RNA component H1 | 0.3560 |
| Midn | midnolin | 0.3735 |
| Notch3 | Notch gene homolog 3 (Drosophila) | 0.3899 |
| Sema5a | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.3949 |
| Gm15401 | predicted gene 15401 | 0.3967 |
| Tgfb1i1 | transforming growth factor beta 1 induced transcript 1 | 0.4005 |
| Taok2 | TAO kinase 2 | 0.4159 |
| Samd4b | sterile alpha motif domain containing 4B | 0.4693 |
Verified by RT-qPCR.
NCBI Gene Expression Omnibus accession numbers GSE49047 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE49047).