Table 4. T/N ratios before, during and after AT-II infusion, and T/N ratio improvement factors in patients with hepatic malignancies.

Author (year)	T/N ratiopre-infusion	T/N ratio during infusion	T/N ratio post-infusion	T/N improvement factor
Sasaki et al. [25]	median 1.36	-	median 4.05	median 3.07 (1.46–5.33)
(1985)	(0.38–3.36)		(1.56–9.33)	p<0.001
Goldberg et al. 1 [33]	median 0.36	-	median 0.75	median 2.80 (0.80–11.70)
(1991)	(0.11–0.90)		(0.10–8.11)	p<0.05
Goldberg et al. 2 [34]	median 3.4	-	median 7.3	median 1.8 (0.5–3.4)
(1991)	(1.3–6.0)		(1.5–8.8)	p<0.05
Burke et al. [19]	median 1.3	median 2.1	median 1.85	NR
(2001)	(0.93–6.21)	(0.63–22.86)	(0.70–18.34)	p  = 0.008 and p  = 0.03*
Ishikawa et al. [36]	median 1.03	-	median 1.34	NR
(2007)	(0.41–1.72)		(0.84–2.09)	p  = 0.01

T/N ratios are described as median (range). P-values correspond to reported significance levels of Wilcoxon test for paired data. *The first p-value refers to the improvement of T/N ratio during infusion and the last to post-infusion. Abbreviations: NR = Not Reported.