Table 1.

Frequencies of Breast Cancer Risk Alleles Among Whites and African Americans in the Carolina Breast Cancer Study, by Race and Case Status, North Carolina, 1993–2001

Gene or Chromosomal Region	SNP	Whites				African Americans
		Risk Allele	RAF Casesa (n = 1,247)	RAF Controlsa (n = 1,105)	HWE P Value	Risk Allele	RAF Casesa (n = 766)	RAF Controlsa (n = 681)	HWE P Value
1p12	rs11249433	G	0.44	0.41	0.54	G	0.14	0.10	0.01
CASP8	rs1045485	G	0.88	0.87	0.63	C	0.06	0.05	0.74
CASP8	rs17468277	C	0.87	0.87	0.63	C	0.95	0.95	0.95
2q35	rs13387042	A	0.54	0.47	0.83	A	0.74	0.73	1.00
2p	rs4666451	G	0.60	0.63	0.30	G	0.78	0.77	0.12
SLC4A	rs4973768	T	0.48	0.42	0.22	T	0.36	0.40	0.05
4p	rs12505080	C	0.29	0.24	0.80	C	0.17	0.17	0.64
TLR1	rs7696175	T	0.45	0.45	0.91	T	0.08	0.06	0.54
MRPS30	rs4415084	T	0.43	0.42	0.18	T	0.64	0.58	0.70
MRPS30	rs10941679	G	0.29	0.30	0.76	G	0.19	0.19	0.17
5p12	rs981782	T	0.53	0.59	0.26	T	0.92	0.91	0.60
5q	rs30099	T	0.10	0.10	0.40	T	0.16	0.12	0.75
MAP3K	rs889312	C	0.32	0.34	0.85	C	0.33	0.36	0.08
ESR1	rs2046210	A	0.36	0.35	0.48	A	0.64	0.61	0.15
ESR1	rs851974	G	0.42	0.43	0.28	G	0.17	0.17	0.46
ESR1	rs2077647	A	0.51	0.49	0.64	A	0.52	0.51	0.16
ESR1	rs2234693	T	0.53	0.57	0.45	T	0.47	0.48	0.63
ESR1	rs1801132	C	0.76	0.76	0.43	C	0.90	0.88	0.36
ESR1	rs3020314	C	0.36	0.34	0.15	C	0.69	0.71	0.75
ESR1	rs3798577	T	0.52	0.53	0.43	T	0.57	0.54	0.27
ECHDC1	rs2180341	G	0.25	0.27	0.55	G	0.31	0.33	0.83
RELN	rs17157903	T	0.13	0.12	0.06	T	0.11	0.10	0.08
8q24	rs13281615	G	0.43	0.42	0.17	G	0.44	0.43	0.58
8q24	rs1562430	T	0.59	0.57	0.78	T	0.54	0.53	0.61
CDKN2A/B	rs3731257	T	0.23	0.23	0.24	T	0.09	0.11	0.89
CDKN2A/B	rs3731249	A	0.03	0.03	0.90	A	0.01	0.00	0.95
CDKN2A/B	rs518394	G	0.44	0.48	0.17	G	0.08	0.08	0.06
CDKN2A/B	rs564398	G	0.42	0.47	0.29	G	0.08	0.08	0.02
CDKN2A/B	rs1011970	T	0.19	0.15	0.62	T	0.33	0.34	0.14
CDKN2A/B	rs10757278	A	0.54	0.55	0.18	A	0.81	0.82	0.77
CDKN2A/B	rs10811661	C	0.17	0.20	0.02	C	0.07	0.07	0.24
ANKRD16	rs2380205	C	0.56	0.60	0.88	C	0.42	0.46	0.72
ZNF365	rs10995190	G	0.86	0.82	0.76	G	0.83	0.83	0.90
ZMIZ1	rs704010	T	0.43	0.42	0.93	T	0.11	0.08	0.82
FGFR2	rs1896395	A	0.00	0.00	0.96	A	0.20	0.20	0.04
FGFR2	rs3750817	C	0.65	0.60	0.16	C	0.91	0.88	0.83
FGFR2	rs10736303	G	0.54	0.49	0.19	G	0.87	0.84	0.75
FGFR2	rs11200014	A	0.46	0.41	0.65	A	0.20	0.21	0.75
FGFR2	rs2981579	T	0.47	0.41	0.51	T	0.62	0.61	0.10
FGFR2	rs1078806	G	0.45	0.41	0.53	G	0.21	0.21	0.99
FGFR2	rs2981578	C	0.54	0.49	0.09	C	0.87	0.84	0.45
FGFR2	rs1219648	G	0.45	0.39	0.35	G	0.44	0.41	0.57
FGFR2	rs2912774	A	0.45	0.40	0.26	A	0.59	0.55	0.07
FGFR2	rs2936870	T	0.45	0.40	0.25	T	0.60	0.56	0.14
FGFR2	rs2420946	T	0.44	0.39	0.21	T	0.54	0.52	0.03
FGFR2	rs2162540	G	0.44	0.39	0.28	G	0.54	0.52	0.41
FGFR2	rs2981582	T	0.44	0.39	0.30	T	0.49	0.49	0.96
FGFR2	rs3135718	G	0.44	0.39	0.23	G	0.58	0.54	0.65
10q	rs10510126	C	0.89	0.89	0.38	C	0.89	0.90	0.21
ATM	rs1800054	G	0.02	0.02	0.34	G	0.00	0.00	0.94
ATM	rs4986761	C	0.02	0.01	0.68	C	0.00	0.00	0.98
ATM	rs1800056	C	0.02	0.01	0.67	C	0.00	0.00	0.95
ATM	rs1800057	G	0.03	0.02	0.90	G	0.01	0.01	0.91
ATM	rs1800058	T	0.02	0.02	0.06	T	0.01	0.01	0.91
ATM	rs1801516	A	0.15	0.14	0.17	A	0.03	0.02	0.48
ATM	rs3092992	C	0.06	0.04	0.13	C	0.01	0.01	0.77
ATM	rs664143	C	0.58	0.57	0.70	C	0.66	0.66	0.45
ATM	rs170548	G	0.31	0.37	0.88	G	0.09	0.12	0.07
ATM	rs3092993	A	0.15	0.14	0.19	A	0.03	0.02	0.48
LSP1	rs3817198	C	0.33	0.34	0.18	C	0.17	0.17	0.16
LSP1	rs909116	T	0.54	0.52	0.20	T	0.71	0.72	0.96
MYEOV	rs614367	T	0.18	0.11	0.05	T	0.13	0.15	0.33
H19	rs2107425	C	0.71	0.68	0.74	C	0.48	0.53	0.42
TOX3	rs8049149	T	0.00	0.00	0.98	T	0.02	0.02	0.32
TOX3	rs16951186	T	0.01	0.01	0.75	T	0.17	0.19	0.95
TOX3	rs8051542	T	0.46	0.44	0.43	T	0.35	0.30	0.12
TOX3	rs12443621	G	0.51	0.41	0.39	G	0.47	0.51	1.00
TOX3	rs3803662	T	0.32	0.24	0.73	C	0.48	0.46	0.65
TOX3	rs4784227	T	0.29	0.22	0.62	T	0.08	0.07	0.59
TOX3	rs3104746	A	0.03	0.02	0.48	A	0.26	0.18	0.87
TOX3	rs3112562	G	0.22	0.20	0.45	G	0.52	0.46	0.88
TOX3	rs9940048	A	0.26	0.24	0.50	A	0.31	0.30	0.64
TP53	rs9894946	G	0.82	0.84	0.48	G	0.95	0.95	0.25
TP53	rs1614984	T	0.41	0.39	0.22	T	0.40	0.40	0.03
TP53	rs4968187	T	0.00	0.00	0.93	T	0.01	0.00	0.92
TP53	rs12951053	C	0.07	0.06	0.47	C	0.11	0.11	0.09
TP53	rs17880604	C	0.02	0.01	0.21	C	0.00	0.00	0.95
TP53	rs1800372	G	0.02	0.02	0.54	G	0.00	0.00	0.98
TP53	rs2909430	G	0.15	0.13	0.66	G	0.27	0.24	0.64
TP53	rs1042522	C	0.75	0.77	0.64	C	0.39	0.43	0.77
TP53	rs8079544	C	0.95	0.95	1.00	C	0.89	0.89	0.83
COX11	rs7222197	G	0.71	0.75	0.60	G	0.66	0.65	0.70
COX11	rs6504950	G	0.71	0.75	0.59	G	0.67	0.65	0.66

Abbreviations: HWE, Hardy-Weinberg equilibrium; RAF, risk allele frequency; SNP, single nucleotide polymorphism.

^a Weighted by inverse sampling probability.