Fig. 4.

Neuropathological features in the hippocampus and subcortical nuclei of the proband. In the hippocampal formation there was marked neuronal loss in the CA4 subregion and dispersion of the granule cells of the dentate fascia (a) and tau immunohistochemistry showed widespread neuronal immunoreactivity, often diffuse in character, and sometimes with additional filamentous inclusions (b, subiculum). Tau-immunoreactive inclusions were widespread in subcortical structures, including: caudate nucleus (c), globus pallidus (d), subthalamic nucleus (e), substantia nigra (f), pontine nuclei (g) and dentate nucleus (h). a H&E; b 4R tau immunohistochemistry; c–h phospho-tau immunohistochemistry (AT8). Bar in a represents 250 μm in a; 50 μm in c–h; 25 μm in b