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. 2013 Sep 25;39(3):569–578. doi: 10.1038/npp.2013.229

Figure 1.

Figure 1

Electrophysiological experiments showing the effect of cocaine on synaptic transmission in corticostriatal slices. (a) A dosage of 10 μM cocaine induced a transient reduction in field potential (FP) amplitude. Each point represents the mean of three responses. Insets show FPs recorded in basal condition (A), 20 min after cocaine application (B) and at the wash-out (C). The horizontal bar indicates the period of drug application. Calibration bars: 0.5 mV, 5 ms. (b) The effect of cocaine (N=10) was significantly reduced by raclopride (N=3) and ZM241385 (N=4), whereas it was unaffected by SCH23390 (N=4). *p<0.05, significantly different from cocaine alone, (the Kruskal–Wallis test). ZM=ZM241385; SCH=SCH23390.