Figure 3.

The synaptic effect of cocaine is modulated by protein phosphatase inhibitors. (a) Time course of cocaine-induced reduction in FP amplitude alone and in the presence of the protein tyrosine phosphatase inhibitor Na₃VO₄, the calcineurin inhibitor FK506, and the protein tyrosine kinase inhibitor PP2. The horizontal bars indicate the period of drug application. (b) The effect of cocaine (N=10) was significantly reduced by Na₃VO₄ (N=5) and FK506 (N=5) but not by PP2 (N=5). **p<0.01, significantly different from cocaine alone (one-way ANOVA).