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. 2013 Oct 2;39(3):625–637. doi: 10.1038/npp.2013.241

Figure 3.

Figure 3

(a) Mice matched for comparable conditioned freezing levels showed similar rates of fear extinction before treatment. After extinction, mice were given amygdala injections of 3 μg (CIQ-3), 10 μg (CIQ-10), 30 μg (CIQ-30), or vehicle (VEH). (b) All groups displayed significantly less freezing at the end of the training session (CS trials 11–15) compared with the start of the session (conditioned stimulus, CS trials 1–5). (c) When tested 1 day after treatment, mice that received 10 μg injections after extinction training (CIQ-10) displayed less conditioned freezing than vehicle animals. No significant differences were detected between the vehicle group and the other treatment groups (p-values>0.05). Number of animals per treatment condition: VEH (n=9), CIQ-3 (n=8), CIQ-10 (n=9), and CIQ-30 (n=8). Error bars denote SEM. Star indicates that the difference between groups was statistically significant (p<0.05).