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. 2013 Oct 23;39(3):727–737. doi: 10.1038/npp.2013.258

Figure 3.

Figure 3

Ganaxolone (GAN) failed to increase the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)/N-methyl-D-aspartate (NMDA) ratio in ventral tegmental area (VTA) dopamine (DA) neurons 24 h after the treatment in γ-aminobutyric acid type-A (GABAA) receptor δ-subunit-knockout (δ-KO) mice. (a) Representative examples of AMPA and NMDA receptor-mediated current traces after GAN 30 mg/kg for wild-type littermate (δ-WT) and δ-KO mice. (b) AMPA/NMDA receptor peak current ratios after vehicle and GAN treatments for δ-WT (vehicle, n=5, and GAN, n=5, where n is the number of tested mice) and δ-KO mice (vehicle, n=5, and GAN, n=9). Calibration: 20 pA/50 ms. Values are shown as means+SEM. ***P<0.001 (ANOVA with Bonferroni test).