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. 2013 Nov 13;39(3):759–769. doi: 10.1038/npp.2013.265

Figure 6.

Figure 6

Accumbal LTD is abolished in slices from naive glutamate receptor-interacting protein (GRIP) KO mice, mimicking what is seen following withdrawal from cocaine. (a) LTD induction by low-frequency stimulation (LFS=1 Hz for 7.5 min) in slices from naive wild-type and GRIP KO mice. (b) Change in fEPSP amplitude across the 30-min post LFS demonstrates a robust LTD in wild-type mice, which is blocked in GRIP KO mice (wild-type: 79.2±5.0%, n=8; GRIP KO: 101±6.0%, n=8; t(14)=2.78, *p=0.015). (c) LFS does not induce LTD in slices from cocaine withdrawn wild-type or GRIP KO mice. (d) Change in fEPSP amplitude across the 30-min post LFS demonstrates that cocaine self-administration and extinction blocks LTD in wild-type mice (wild-type: 98.7±9.2%, n=6; GRIP KO: 103±6.6%, n=7).