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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: JAMA Neurol. 2013 Feb;70(2):229–234. doi: 10.1001/jamaneurol.2013.592

Figure.

Figure

Voltage-gated potassium channel (VGKC) values and frequency of contactin-associated protein-like 2 (CASPR2) IgG and leucine-rich glioma-inactivated protein 1 (LGI1) IgG detection. Voltage-gated potassium channel complex IgG binds to LGI1 or CASPR2 in only a minority of cases. The frequency of LGI1 IgG and CASPR2 IgG detection by cell-binding assay stratified into 3 subgroups based on VGKC complex IgG values shows a range of values associated with CASPR2 IgG and LGl1 IgG detection. A, The VGKC complex IgG values (y-axis) of patients identified as positive for CASPR2 IgG (green circles), LGI1 IgG (red circles), both CASPR2 IgG and LGI1 IgG (blue circles), or negative for both (black dots). The dashed line indicates the frequency of LGI1 IgG and/or CASPR2 IgG in seropositive patients whose VGKC complex IgG values exceed or are less than 0.40 nmol/L. B, The percentage of subtyped antibodies based on VGKC complex IgG values.