Table 1.
Neurologic Accompaniments Stratified Serologically by High, Medium, and Low Serum VGKC Complex IgG Values
| Neurologic Accompaniment Level Involved or Manifestation |
Patients With Specific Neurologic Accompaniment, No. (%) |
P Valuea | |||
|---|---|---|---|---|---|
| Value |
|||||
| Total (n = 316) |
High (≥1.00 nmol/L) (n = 28) |
Medium (0.10-0.99 nmol/L) (n = 179) |
Low (0.03-0.09 nmol/L) (n = 109) |
||
| Cerebral cortex | 144 (45.6) | 19 (67.9) | 87 (48.6) | 38 (34.9) | .007 |
| Cognitive impairment | 70 (22.2) | 13 (46.4) | 33 (18.4) | 24 (22.0) | .004 |
| Seizure | 33 (10.4) | 8 (28.6) | 20 (11.2) | 5 (4.6) | <.001 |
| Frontosubcortical | 10 (3.2) | 0 | 8 (4.5) | 2 (1.8) | >.05 |
| Depression/anxiety/agitation | 52 (16.5) | 4 (14.3) | 36 (20.1) | 12 (11.0) | >.05 |
| Hypothalamic | |||||
| Hyponatremia | 6 (1.9) | 3 (10.7) | 3 (1.7) | 0 | >.05 |
| Dyssomnia | 15 (4.7) | 4 (14.3) | 6 (3.4) | 5 (4.6) | |
| Hypersomnia | 9 (2.8) | 1 (3.6) | 4 (2.2) | 4 (3.7) | >.05 |
| Insomnia | 6 (1.9) | 3 (10.7) | 2 (1.1) | 1 (0.9) | >.05 |
| Extrapyramidal | 11 (3.5) | 2 (7.1) | 5 (2.8) | 4 (3.7) | >.05 |
| Tremor | 7 (2.2) | 2 (7.1) | 4 (2.2) | 1 (0.9) | >.05 |
| Parkinsonism | 3 (0.9) | 0 | 1 (0.6) | 2 (1.8) | >.05 |
| Chorea | 2 (0.6) | 0 | 1 (0.6) | 1 (0.9) | >.05 |
| Cranial nerve brainstem | 2 (0.6) | 1 (3.6) | 0 | 1 (0.9) | >.05 |
| Cerebellum | 6 (1.9) | 0 | 4 (2.2) | 2 (1.8) | >.05 |
| Spinal cord | 9 (2.8) | 0 | 7 (3.9) | 2 (1.8) | >.05 |
| Peripheral autonomic nerve | 95 (30.1) | 7 (25.0) | 51 (28.5) | 37 (33.9) | >.05 |
| Gastrointestinal | 29 (9.2) | 1 (3.6) | 14 (7.8) | 14 (12.8) | >.05 |
| Genitourinary | 4 (1.3) | 0 | 4 (2.2) | 0 | >.05 |
| Blood pressure | 23 (7.3) | 2 (7.1) | 12 (6.7) | 9 (8.3) | >.05 |
| Sudomotor | 41 (12.3) | 4 (14.3) | 22 (12.3) | 15 (13.8) | >.05 |
| Peripheral somatic nerve | 109 (34.5) | 6 (21.4) | 63 (32.9) | 40 (33.0) | >.05 |
| Hyperexcitability, motor | 46 (14.5) | 2 (7.1) | 26 (14.5) | 18 (16.5) | >.05 |
| Neuropathy, sensorimotor | 52 (16.5) | 4 (14.3) | 30 (16.8) | 18 (16.5) | >.05 |
| Small fiber sensory | 11 (3.5) | 0 | 7 (3.9) | 4 (3.7) | >.05 |
| Motor neuron | 7 (2.2) | 1 (3.6) | 3 (1.7) | 3 (2.8) | >.05 |
| Myoclonus | 4 (1.3) | 1 (3.6) | 1 (0.6) | 2 (1.8) | >.05 |
| Stiff-person phenomena | 2 (0.6) | 0 | 1 (0.6) | 1 (0.9) | >.05 |
| Morvan syndrome | 1 (0.3) | 0 | 1 (0.6) | 0 | >.05 |
| Headache | 13 (4.1) | 0 | 10 (5.6) | 3 (2.8) | >.05 |
| Gait disorder not specified | 19 (6.0) | 0 | 13 (7.3) | 6 (5.5) | >.05 |
| Vision loss | 8 (2.5) | 0 | 6 (3.4) | 2 (1.8) | >.05 |
| Pain only | 45 (28.0) | 4 (14.3) | 27 (15.1) | 14 (12.8) | >.05 |
Abbreviation: VGKC, voltage-gated potassium channel.
a
Comparison of 3 serologic subgroups.