TABLE II.
Recombinant Human Bone Morphogenetic Protein-2 Treatment Effects on Xenograft Histology.
| UMSCC-14A |
UMSCC-74A |
|||||
|---|---|---|---|---|---|---|
| Histopathologic Characteristics | Control (%) | BMP-2 (%) | Fisher's exact test (p-value) | Control(%) | BMP-2 (%) | Fisher's exact test (p-value) |
| Histological Grade: | ||||||
| Moderate | 100 | 50 | 0.0294 | 0 | 0 | 0.1222 |
| Poor | 0 | 50 | 40 | 7 | ||
| Poor with Spindle Cells | 0 | 0 | 60 | 86 | ||
| Spindle Cell Carcinoma | 0 | 0 | 0 | 7 | ||
| Host Inflammation: | ||||||
| None | 11 | 0 | 0.0216 | 20 | 43 | 0.3875 |
| Minimum | 78 | 25 | 80 | 57 | ||
| Mild | 11 | 25 | 0 | 0 | ||
| Brisk | 0 | 50 | 0 | 0 | ||
| Pattern of invasion: | ||||||
| Infiltrative | 44 | 25 | 0.6199 | 60 | 64 | 1.0000 |
| Pushing | 56 | 75 | 40 | 36 | ||
| Perineural invasion: | ||||||
| Yes | 0 | 0 | – | 10 | 8 | 1.0000 |
| No | 100 | 100 | 90 | 92 | ||
| Lymphovascular space invasion: | ||||||
| Yes | 33 | 38 | 1.0000 | 0 | 31 | 0.1045 |
| No | 67 | 62 | 100 | 69 | ||
The histopathologic characteristics between tumors established after treatment with recombinant human bone morphogenetic protein-2 and control were compared. P values for the treatment effects are shown. P values <.05 were considered significant. BMP-2 = bone morphogenetic protein-2.