Figure 1.

Central mediators of steatosis activated by CB₁R. Green boxes indicate increased activity; red ones decreased activity. Abbreviations are as follows: ACC, acetyl-CoA carboxylase; AMPK, AMP-activated protein kinase; CB₁R, cannabinoid 1 receptor; CPT1, carnitine palmitoyltransferase I; FAS, fatty acid synthase; LKB1, liver kinase B1; LXRα, Liver X receptor alpha; mTORC1, mammalian target of rapamycin complex 1; PKA, protein kinase A; SREBP-1c, sterol regulatory element-binding protein 1c