Table 3.

Example of a multiple adjusted indirect comparison Kim et al. [9]). In order to compare sitagliptin with insulin in T2DM with respect to change in HbA1c, links were made via sitagliptin vs. placebo, exenatide vs. placebo and insulin vs. exenatide

	Sitagliptin vs. placebo	Exenatide vs. placebo	Insulin vs. exenatide
Results of the head-to-head clinical trials: (absolute change in HbA1c)	0.57 (95% CI: 0.45, 0.72)	0.52 (95% CI: 0.32, 0.92)	0.40 (95% CI: 0.27, 0.60)
Adjusted indirect comparison: sitagliptin vs exenatide using placebo as common comparator	0.30 (95% CI: 0.17, 0.53)
Adjusted indirect comparison: sitagliptin vs insulin using exenatide as common comparator	0.74 (95% CI: 0.40, 1.37)

CI, confidence interval.