Fig. 4.

Knockdown of CLDN1 (siCLDN1) induced increased migration potential. Boyden chamber assay revealed altered migration in 64% of siCLDN1-treated adaCP tumor cell cultures compared with control RNAi-transfected cells (siNC) (Fig. 4A; *P < .05; **P < .01). Overall significance was given (Fig. 4B; P = .0121), although one sample offered a significant reduction of cell migration. Abbreviations: adaCP, adamantinomatous craniopharyngioma; CLDN1, claudin-1; siCLDN1, small interfering claudin-1RNA; siNC, small interfering negative control RNA