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Figure 6. PTEN mediated regulation of Rad52 sumoylation. (A) HeLa cells were transfected with luciferase siRNAs (siLuc) or PTEN siRNAs (siPTEN) for 24 h and then treated with 1 mM H2O2 for various times as indicated. Cells were collected and chromatin-bound proteins were obtained. Equal amounts of protein lysates were then blotted for Rad52, PTEN, and actin. (B) A model of PTEN regulation in response to DNA damage induced by genotoxic stresses.
