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. Author manuscript; available in PMC: 2014 Jan 19.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2010 Jan-Feb;2(1):34–48. doi: 10.1002/wsbm.49

Figure 4. Example of spatial stochastic modeling.

Figure 4

Panel A shows a schematic of an M-Cell model used to model cardiac myocyte dyadic clefts (the narrow space between the cell membrane and sarcoplasmic reticulum). Calcium ions are shown in red, L-type calcium channels in blue, and ryanodine receptors in yellow. Panel B shows an example of an M-Cell simulation showing calcium signaling in the dyadic cleft. M-Cell tracks the location, random movement, and identity of each molecule within the system volume, thereby providing a spatial stochastic simulation. (Reprinted with permission from Fig. 1 of Reference [122]).