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. Author manuscript; available in PMC: 2014 Jan 19.
Published in final edited form as: Proteomics. 2012 May;12(10):1547–1564. doi: 10.1002/pmic.201100520

Figure 2.

Figure 2

Several MS datasets from the literature are highlighted, and illustrated in context relative to how they might be used in a broader determination of a three-dimensional protein interactome model. These include studies of monomeric protein structure a) gp120-based antigen [70] and b) β-immuoglobulin [51]. Binary protein or protein-ligand systems can also be studied by MS, as in the cases of c) the GPCR-rodopsin complex [71] and d) the S100A11 dimer [69]. Finally, the structure of multiprotein systems can be studied by MS as in the cases of e) the RNA polymerase II [99] and f) the yeast exosome [182]. Each pair of data is contained within color-coded regions that correspond to the same shaded area of the 3D protein interactome cartoon at the center of the figure.