Table 3.
Characteristics of endometrial cancer cases with immunohistochemical loss of MLH1 and absence of MLH1 methylation (presumed Lynch Syndrome) that were incorrectly designated as sporadic by SGO criteria
| Case | Age at EC Diagnosis1 | BMI | DM2 | Family History of EC | Family History of CRC3 | Meets Amsterdam II Criteria | Tumor Location (Corpus or LUS4) | FIGO Stage | Tumor Grade | Tumor Size (cm) | Histology5 | Depth of Uterine Wall Invasion |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 61 | 51.8 | No | Cousin age > 50 | No | No | Corpus | II | 1 | 13 | E | > 50% |
| 2 | 64 | 30.9 | No | No | No | No | LUS | II | 1 | 3 | C | > 50% |
| 3 | 71 | 38 | Yes | Mother unknown gyn cancer age > 50 | No | No | Corpus | IA | 2 | 5.5 | M | < 50% |
| 4 | 79 | 31 | Yes | No | No | No | Corpus | IIIC2 | 2 | 1.9 | E | > 50% |
1
EC, endometrial cancer
2
DM, diabetes mellitus
3
CRC, colorectal cancer
4
LUS, lower uterine segment
5
E, endometrioid carcinoma; C, clear cell carcinoma; M, mixed endometrioid and sarcomatoid carcinoma