Figure 1. The multifaceted effects of cell senescence.

Senescence is a well- established tumor suppression process. Senescence is likely also important for wound healing, and perhaps for generation of terminally differentiated cells in the body, highlighting the importance of senescence in normal physiology. On the darker side, senescence may also contribute to tissue aging. The secretome and senescence-associated inflammation have been proposed to contribute to tumorigenesis.